Diabetic Complications - Can Benfotiamine Help Prevent Them?

Diabetic complications contribute too many life threatening diseases globally. The root cause of diabetic complications is elevated glucose levels which contribute to blood vessel damage. Diabetic retinopathy, nephropathy, or neuropathy are caused by damage to small blood vessel in the eyes, nerves and kidneys, etc. The bottom line of this damage is the lowering of the life expectancy of millions of diabetics worldwide.

What Can Be Done About It?

Few therapies are available today that treat diabetic complications. Most healthcare professionals recommend that their patients monitor their blood sugar by taking several blood readings a day to determine the amount of sugar in their blood. Blood sugar readings are generally higher from one to two hours after a meal.

It is suggested by these professionals that keeping blood sugar readings as close to normal as possible will reduce the onset of diabetic complications. Research has shown that there are four, chemical pathways that lead to diabetic complications. Instead of trying to explain these rather difficult chemical pathways, let the reader understand that diabetic complications are mainly caused by excess sugar in the cells, a condition known by the term advanced glycation endproducts (AGE) formation.

The research that was released in 2003 by a team of researchers from the Albert Einstein Collage of Medicine opened the possibilities that it may be possible to actually prevent and/or contain diabetic complications such as retinopathy, neuropathy and heart/circulatory conditions brought about by the presence of advanced glycation endproducts.

What Did This Research Suggest?

The Einstein researchers' work showed that a substance called, "benfotiamine", could reduce the effects of AGE by increasing the amount of an enzyme called transketolase. The research indicated that transketolase was increased by 300% which was enough to make a serious reduction of three of the four chemical pathways that open the door for diabetic complications in terms of vascular damage in diabetics. This vascular damage is directly responsible for the diabetic complications such as neuropathy, retinopathy and heart/circulatory conditions that lead to heart attack and stroke.

Can Benfotaimine Be Considered A Prudent Preventative?

Current research suggests that benfotiamine could possibly reduce the chances of diabetics developing the aforementioned complications. Many healthcare professionals readily recommend patients to add this nutritional supplement to their toolkit in the battle to prevent these insidious conditions that shorten the lives of thousands of diabetics annually.

Research:

Hans-Peter Hammes, Xueliang Du, Diane Edelstein, Tetsuya Taguchi, Takeshi Matsumura, Qida Ju, Jihong Lin, Angelika Bierhaus, Peter Nawroth, Dieter Hannak, Michael Neumaier, Regine Bergfeld, Ida Giardino, Michael Brownlee. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Medicine 9, 294 - 299 (01 Mar 2003).

Michael Brownlee. Biochemistry and molecular cell biology of diabetic complications Nature 414, 813 - 820 (13 Dec 2001).

Roya Babaei-Jadidi, Nikolaos Karachalias, Naila Ahmed, Sinan Battah, Paul J. Thornalley. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine ? Complications. Diabetes. (August 2003).

Zach Malott is CEO of Brentwood Health International, a nutritional supplement company involved in distribution and supplying wholesale, retail and end users.

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